Mechanism of Drug Loading, Evaluation and Applications of Erythrocytes as Carriers for Drug Targetting

Resealed Erythrocytes are of appropriate size and shape to carry drugs. They are biocompatible and they have minimum toxic side effects. Minimum leakage can be observed before they reach the target site and they are able to carry broad spectrum of drugs. Carrier erythrocytes and resealed erythrocytes are being used for continuous implementation of safe and effective delivery of various drugs for passive and active targeting. Further optimization is required to become a routine drug delivery system which has been extended to the delivery of biopharmaceuticals and to be explored continuously regarding the potential of encapsulated erythrocytes. Resealed erythrocytes and loaded erythrocytes allow controlled drug release and increased specificity of delivery to the targeted organ. This review focus on various methods of encapsulated erythrocytes preparation, techniques of drug loading such as electroencapsulation, chemical perturbation, entrapment by endocytosis etc, mechanism of resealed erythrocyte release and evaluation resealed erythrocytes.